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By Alisa Zapp Machalek

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COX-2 (cyclooxygenase-2) | An enzyme found in only a few places, such as the brain and AZT (azido-deoxythymidine) | A drug used parts of the kidney. It is made only in response to treat HIV. It targets the reverse transcriptase enzyme. to injury or infection. It produces prostaglandins Bacterium (pl. bacteria) | A primitive, one-celled involved in inflammation and the immune response. microorganism without a nucleus. Bacteria live NSAIDs act by blocking COX-2. Because elevated almost everywhere in the environment.

Structures. It uses X-rays of different wavelengths, relieving crystallographers from having to make several different metal-containing crystals. Nuclear Overhauser effect spectroscopy (NOESY) | An NMR technique used to help determine protein structures. It reveals how close NMR | Nuclear magnetic resonance. NMR-active atom | An atom that has the correct magnetic properties to be useful for NMR. For some atoms, the NMR-active form is a rare isotope, such as 13C or 15 N. NOESY | Nuclear Overhauser effect spectroscopy.

The natural magnets in the molecule. The higher the peak, the more hydrogen sample’s atoms line up with the NMR magnet atoms it represents. The position of the peaks on just as iron filings line up with a toy magnet. the horizontal axis indicates their chemical identity. The researchers then blast the sample with a series The overlapping peaks typical of one- of split-second radio wave pulses that disrupt this dimensional NMR spectra obscure information magnetic equilibrium in the nuclei of selected atoms.

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