By D. Stanley Eitzen
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23) developed by Sanofi-Aventis under the name SR147778. 5 nM), along with low affinity to human CB2 receptors (Ki = 400 nM) . It has being investigated, in view of potential advantages over Rimonabant (70) , as a potential treatment for nicotine addiction to assist smoking cessation. It may also be developed as an anorectic drug to assist with weight loss. CP-945,598, or Otenabant (, Fig. 24), is a diphenyl purine which acts as a potent and highly selective CB1 antagonist. 7 nM for CB1 receptors and a selectivity >10,000-fold over CB2 .
IUPAC Numbering System—cont’d Type Skeleton Iso-THC-type iso-THC 2 +2 Cannabicyclol-type CBL D D F E 2 D +2 Cannabicitran-type CBT 2 2 of THC levels in the brain and produces some typical effects of cannabinoids when administered at high doses such as decrease of motor activity, antinociception, catalepsy, hypothermia, and antiedematous effects, but through a mechanism different from the interaction with cannabinoid receptors, as happens with Δ9-THC .