By YANG DECHENG
This can be the 1st finished e-book on human/animal gene responses to RNA viral infections, together with time-honored, rising and re-emerging RNA viruses resembling HIV, SARS-CoV, West Nile virus, influenza virus and so forth. Human gene responses are reviewed through major virologists around the world within the following facets: the altered gene expression profiles on the transcriptional and translational degrees detected with state of the art applied sciences equivalent to cDNA microarray and proteomics; host innate and tailored immune responses to viral replication in goal organs; virus-activated sign transduction pathways in telephone survival, apoptosis and autophagosomal pathways; and, the small interfering RNA/microRNA-mediated gene silencing pathway, a lately characterised new host safety mechanism opposed to viral infection.Organized into 29 hugely obtainable and well-illustrated chapters, this quantity explores state of the art wisdom of the molecular mechanisms of RNA virus an infection and host-virus interactions. This complete compilation of the altered gene expression profiles and sign transduction pathways in host cells according to the vast majority of human/animal RNA viruses opens new instructions for simple and scientific study on viral pathogenesis, and in addition presents helpful biomarkers for researchers to pick gene objectives within the improvement of diagnostic exams and antiviral therapeutics for a few infectious ailments.
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Additional info for RNA Viruses: Host Gene Responses to Infections
16 This suggests that selected host miRNAs may be involved in mediating viral latency, possibly explaining latency in quiescent cells. 17 Interestingly, HIV infection has also been associated with the upregulation of RNA editing enzymes, such as ADAR in vitro and in vivo,18,19 and could potentially alter miRNA target sequences within the viral genome to bypass miRNA-mediated repression. Whether this is relevant to the maintanence of viral latency should be an active area of future research. 5 Viral entry through cellular receptors HIV-1 enters cells by first attaching to the target cell, followed by fusion between the virus and cell membranes.
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