Download Reviews of Environmental Contamination and Toxicology Volume by Pim de Voogt PDF

By Pim de Voogt

Reviews of Environmental infection and Toxicology makes an attempt to supply concise, serious experiences of well timed advances, philosophy and critical components of finished or wanted undertaking within the overall box of xenobiotics, in any section of our surroundings, in addition to toxicological implications.

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Denslow Tyne estuary. The inductions of CYP1A, UDP-glucuronosyltransferase (UDPGT) and aldehyde dehydrogenase mRNA in the liver of flounder suggested that Tyne estuary is contaminated with polycyclic aromatic hydrocarbons (PAHs). Moens et al. (2007b) conducted a chronic toxicity test by exposing common carp to effluent for 21 days under flow-through conditions. Microarray analysis revealed that effluent treatment affected molecular pathways associated with the energy balance of the fish, including changes in carbohydrate and lipid metabolism, as well as digestive enzyme activity.

2014). Microarray analysis of 175-gene array from medaka revealed that alteration in hepatic gene expression and histological changes are strongly dependent on dose and time (Volz et al. 2006). Liu et al. (2014) showed that altered genes in response to TCDD were involved in pathways associated with cardiac necrosis/ cell death, cardiac fibrosis, renal necrosis/cell death, and liver necrosis/cell death. In another study, Hofsteen et al. (2013) revealed that TCDD exposure inhibit the regeneration of heart muscle and also alters the pattern of gene expression induced by wounding at the ventricle in zebrafish.

Therefore, new and efficient data-mining programs and comparative genomic tools are required to explore and interpret data in a time frame compatible with the rate at which they are generated. 9 Summary and Conclusion Gene expression analysis is one of the most widely used techniques in detecting and elucidating molecular responses to toxicants. Over the last 10 years by the introduction and widespread adoption of toxicogenomic techniques in fish toxicology has made a paradigm shift from studying expression patterns of single or few molecular endpoints to genome wide expression response.

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