Download Review of Medical Physiology (LANGE Basic Science) by William F. Ganong PDF

By William F. Ganong

This ebook presents a present and concise review of mammalian and human body structure. Examples from scientific drugs were built-in in the course of the chapters to light up very important physiologic strategies. The publication comprises greater than seven-hundred beautiful and informative illustrations. A important self-study advisor, which positive factors content material summaries, targets, essay questions, and multiple-choice questions, is equipped on the finish of the publication and is a superb device for college kids whilst reviewing for the USMLE and different examinations.

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The mitochondria are the power-generating units of the cell and are most plentiful and best developed in parts of cells where energy-requiring processes take place. The chemical reactions occurring in them are discussed in detail in Chapter 17. The outer membrane of each mitochondrion is studded with the enzymes concerned with biologic oxidations, providing raw materials for the reactions occurring inside the mitochondrion. In the interior, the enzymes that convert the products of carbohydrate, protein, and fat metabolism to CO2 and water are located in the internal mitochondrial membrane.

Connexon isoforms are encoded by at least 13 different genes in rodents, and it seems likely that there are at least this many different genes that are involved in humans. There is considerable variation in distribution of the isoforms from one tissue to another. In mice, the ovum is connected to granulosa cells by tight junctions, and mice deficient in one type of connexon fail to ovulate and complete meiosis. A number of diseases in humans have been linked to mutant connexons. One is the X-linked form of Charcot-Marie-Tooth disease, a peripheral neuropathy, and another is heterotaxia, in which there are multiple abnormalities with failure to establish normal left-right asymmetry.

Some are gated by alterations in membrane potential (voltage-gated), whereas others are opened or closed when they bind a ligand (ligand-gated). The ligand is often external, eg, a neurotransmitter or a hormone. However, it can also be internal; intracellular Ca2+, cAMP, lipids, or one of the G proteins produced in cells (see below) can bind directly to channels and activate them. Some channels are also opened by mechanical stretch, and these mechanosensitive channels play an important role in cell movement.

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