Download QSAR in Environmental Toxicology: Proceedings of the by R. J. Allan (auth.), Klaus L. E. Kaiser (eds.) PDF

By R. J. Allan (auth.), Klaus L. E. Kaiser (eds.)

Ever when you consider that Rachel Carson's Silent Spring, we've got ordinarily observe environmental contaminants and their results at the atmosphere. The findin~ of PCB's in fish by way of Soren Jensen in Sweden, the popularity of mirex as contaminant in fish from Lake Ontario, and the discoveries of contaminant weighted down leachates from dumpsites equivalent to the affection Canal became milestones within the look for and charac­ terization of contaminants in the environment. at present, the matter now not is lots the identifi­ cation of contaminants and their assets. relatively, we're now confronted with fixing questions about the fates and results of such compounds. This comprises the hunt for mechanisms to deal successfully with the big variety of chemical substances already present in water, air and biota. one in every of such time and price saving clinical avenues is the sphere of quantitative structure-activity correlations for the prediction of the environmental habit and results of compounds.

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Read Online or Download QSAR in Environmental Toxicology: Proceedings of the Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology held at McMaster University, Hamilton, Ontario, Canada, August 16–18, 1983 PDF

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Extra info for QSAR in Environmental Toxicology: Proceedings of the Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology held at McMaster University, Hamilton, Ontario, Canada, August 16–18, 1983

Sample text

CHU ET AL. 0 SO 500 a b Figures denote animals showing lesions/animals examined. Only control animals and those on the highest dose groups were examined. TOXICITY AND METABOLISM OF TETRACHLOROBENZENES thyroid was compounds more dose-dependent. on the thyroid, 27 Comparing the relative effect of these it was apparent that 1,2,4,5-TCB was the active level of than the other two isomers. Even at the highest dose these chemicals the changes were considered mild. Changes elicited by the administration of 1,2,3,4- and 1,2,3,5-TCB were very mild in terized nature.

All animals were examined grossly at the time of necropsy. Serum biochemical determinations were made using a Technicon microanalyzer, model 12/60 and included sodium, potassium, inorganic phosphate, total bilirubin, phosphatase, glutamic oxalacetic transaminase (GOT), total alkaline protein, calcium, cholesterol, glucose, uric acid and lactic dehydrogenase. Sorbitol dehydrogenase (SDH) activity was determined according to an ,automated method previously described (Yagminas and Villeneuve 1977).

1,2,3,4-TCB was metabolized to 2,3,4,5- and 2,3,4,6-tetrachlorophenol, 2,3,4-trichlorophenol and a tetrachlorothiophenol (SCHEME 1). Based on these metabolites two arene oxide intermediates may be involved: 2,3,4,5- and 3,4,5,6-tetrachlorobenzene-oxide (TCBO). The formation of 2,3,4,6-tetrachlorophenol suggests that 2,3,4,5-TCBO is the only intermediate which rearranges to yield the product through the NIH shift (Jerina and Daly 1974). 2,3,4,5-tetrachlorophenol, on the other hand, may be formed by a spontaneous rearrangement of 2,3,4,5- and/or 3,4,5,6-TCBO.

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