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By Sönke Svenson

content material: v. 1. Pariculate drug vendors --
2. Polymeric matrices and drug particle engineering.

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2 60 0 +0 2 • 4 . 6 • 8 • 10 12 1 14 Days Figure 7. Comparison of model predictions and experimental release data for lysozyme from PLA-NMP system. 39. All other parameters same as Figure 6. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. 27 PLA-NMP System Figure 7 shows a comparison between the model predictions and the lysozyme release data of DesNoyer and McHugh (5) from P L A - N M P solutions. In this case, since the physical characteristics of the polymers are similar, the value used for the Nusselt number was that obtained from the P L G A - N M P fit.

PACLIMER®-treated groups (n=6 per group). In the first experiment, animals were treated at day 4 with paclitaxel or PACLIMER® at 10 mg/kg and 40 mg/kg doses. In the second experiment, efficacy of PACLIMER® at 4, 10 and 40 mg/kg were compared with paclitaxel at 40 mg/kg. Another study was conducted using O V C A R 3 animal model. The study design was similar to the previous study with the exception that treatment started at day 1 post cell inoculation. The treatment groups were: placebo control (n=20), PACLIMER® at 160 mg/kg (n=9), 80 mg/kg (n=10), 40 mg/kg (n=10), 4 mg/kg (n=10), paclitaxel at 40 mg/kg (n=10), 4 mg/kg (n=10) and 4 weekly treatment at 40 mg/kg (n=9).

In the first experiment, animals were treated at day 4 with paclitaxel or PACLIMER® at 10 mg/kg and 40 mg/kg doses. In the second experiment, efficacy of PACLIMER® at 4, 10 and 40 mg/kg were compared with paclitaxel at 40 mg/kg. Another study was conducted using O V C A R 3 animal model. The study design was similar to the previous study with the exception that treatment started at day 1 post cell inoculation. The treatment groups were: placebo control (n=20), PACLIMER® at 160 mg/kg (n=9), 80 mg/kg (n=10), 40 mg/kg (n=10), 4 mg/kg (n=10), paclitaxel at 40 mg/kg (n=10), 4 mg/kg (n=10) and 4 weekly treatment at 40 mg/kg (n=9).

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