Download Kaplan Medical USMLE Step 1 Lecture Notes: Pharmacology by Craig Davis, Steven R. Harris PDF

By Craig Davis, Steven R. Harris

Those are Adobe Clearscan PDF documents generated from six hundred dpi scans of the Kaplan USMLE Step 1 Lecture Notes which have been disbursed to scholars in Kaplan scientific prep classes in 2014.

The following preface references 7 volumes. This includes in basic terms the Pharmacology volume.

These 7 volumes of Lecture Notes signify the most-likely-to-be-tested fabric at the present USMLE Step 1 examination. Please observe that those are Lecture Notes, no longer evaluate books. The Notes have been designed to be followed through school lectures­ reside, on video, or on the net. interpreting them with out getting access to the accompanying lectures isn't a great way to check for the USMLE.

To maximize the effectiveness of those Notes, annotate them as you hearken to lec­tures. To facilitate this procedure, we've created huge, clean margins. whereas those margins are sometimes punctuated through college high-yield "margin notes:' they're, for the main half, left clean to your notations.

Many scholars locate that previewing the Notes ahead of the lecture is a really effec­tive strategy to organize for sophistication. this lets you expect the parts the place you'll have to pay specific consciousness. It additionally provides you the chance to map out how the data goes to be offered and how much learn aids (charts, diagrams, etc.) you want to upload. This procedure works whether you're attending a reside lecture or gazing one on video or the web.

Finally, we wish to pay attention what you think that. What do you love concerning the Notes? What can be greater? Please percentage your suggestions by way of e-mailing us at med.feedback@ kaplan.com.

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Additional info for Kaplan Medical USMLE Step 1 Lecture Notes: Pharmacology (2013)

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Pharmacologic responses elicited via modification of gene expression are usually slower in onset but longer in duration than many other drugs. Membrane Receptors Directly Coupled to Ion Channels • Many drugs act by mimicking or antagonizing the actions of endog­ enous ligands that regulate flow of ions through excitable membranes via their activation of receptors that are directly coupled (no second messengers) to ion channels. • For example, the nicotinic receptor for ACh (present in autonomic ner­ vous system [ANS] ganglia, the skeletal myoneural junction, and the central nervous system [CNS]) is coupled to a Na+/K+ ion channel.

Drug Properties of Direct-Acting Cholinomimetics Activity AChE Clinical Uses Hydrolysis A Ch M and N Bethanechol M +++ Short half-life-no clinical use Rx-ileus {postop/neurogenic), urinary retention Methacholine M>N Pilocarpine M + Ox-bronchial hyperreactivity Rx-glaucoma (topical), xerostomia � MEDICAL 47 Section II • Autonomic Pharmacology Clinical Correlate Alzheimer Disease Late-onset dementia with progressive memory loss and cognitive decline. Acetylcholinesterase Inhibitors Table 11-2-5. Properties of Indirect-Acting Cholinomimetics Drug Characteristics Edrophonium Short-acting Neuropathology includes neurofibrillary tangles, amyloid plaques, and loss of Clinical Uses Dx-myasthenia; used to ACh neurons in Meynert's nucleus­ differentiate myasthenia from rationale for clinical use of AChE cholinergic crisis inhibitors.

Receptors Using Cyclic AMP and IP3, DAG, Ca2+ as Second Messengers Cyclic GMP and Nitric Oxide Signaling • • cGMP is a second messenger in vascular smooth muscle that facilitates Bridge to Biochemistry See Chapter 9 of the Biochemistry dephosphorylation of myosin light chains, preventing their interaction Lecture Notes for additional discussion with actin and thus causing vasodilation. of signal transduction. Nitric oxide (NO) is synthesized in endothelial cells and diffuses into smooth muscle.

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