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By B. Beek

The bioaccumulation of endocrine disruptors, power natural chemical compounds and different compounds of excessive environmental influence has develop into of accelerating curiosity in latest environmental study, chance research and toxicology. This quantity offers an updated evaluation and introduces the reader to the recent proposal of "internal influence focus" linking bioaccumulation and biomagnification within the nutrients chain to ecotoxicology and probability evaluation.

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136]. All data from Ref. [136] as otherwise noted. b Schweinfurth et al. (Shake-flask method) [168]. c Data from Ahel and Giger [169]. d Bioconcentration of 14C-NP determined by Ekelund et al. [170]. e Bioconcentration in zebrafish determined by the kinetic method by Butte et al. [171]. ) [172]. g Determined by the HPLC method by Butte et al. [172]. h Range of BCF values of PCP in mussels and different fish species compiled from the literature by Geyer et al. [173a]. W i Mean BCF value calculated by Geyer et al.

There are also indications that organic chemicals can interact with the binding of natural hormones to two or more receptors. Some environmental endocrine-disrupting chemicals classified as estrogens can bind to more than one steroid receptor. For example, chlordecone (Kepone) and o,p¢-DDT can bind to the estrogen (ER) and progesterone receptors (PR) with each chemical having IC50 values that are nearly identical for the two receptors [123, 124a, b]. ] Other environmental chemicals, such as p,p¢-DDT, p,p¢-DDD, and p,p¢DDE can bind to the androgen receptor (AR) 14, 11, and 200 times more effectively, respectively, than to the estrogen receptor [124a, 125a].

C Data from Ahel and Giger [169]. d Bioconcentration of 14C-NP determined by Ekelund et al. [170]. e Bioconcentration in zebrafish determined by the kinetic method by Butte et al. [171]. ) [172]. g Determined by the HPLC method by Butte et al. [172]. h Range of BCF values of PCP in mussels and different fish species compiled from the literature by Geyer et al. [173a]. W i Mean BCF value calculated by Geyer et al. [173a]. L j Tetrabromobisphenol-A showed no estrogenic effects in an eucaryotic test system (K.

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