Download Basic and Clinical Pharmacology (12th Edition) (LANGE Basic by Bertram G. Katzung, Susan Masters, Anthony Trevor PDF

By Bertram G. Katzung, Susan Masters, Anthony Trevor

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The newest, finished, and authoritative pharmacology textual content in overall healthiness medicine
Enhanced by means of greater than 300 illustrations -- many in complete color

Organized to mirror the syllabi in lots of pharmacology classes and in built-in curricula, Basic & scientific Pharmacology, 12e covers the real recommendations scholars want to know concerning the technology of pharmacology and its software to medical perform. number of the subject material and order of its presentation are in response to the authors’ a long time event in educating this fabric to hundreds of thousands of clinical, pharmacy, dental, podiatry, nursing, and different healthiness technological know-how students.

To be as clinically appropriate as attainable, the booklet contains sections that particularly handle the medical selection and use of gear in sufferers and the tracking in their results, and case reports that introduce medical difficulties in lots of chapters. awarded in complete colour and more advantageous by means of greater than 300 illustrations, Basic & scientific Pharmacology positive aspects quite a few precis tables and diagrams that encapsulate vital information.

Coverage that spans each point of scientific pharmacology:
• easy principles
• Autonomic drugs
• Cardiovascular-renal drugs
• medicinal drugs with vital activities on gentle muscles
• valuable frightened process drugs
• medicines used to regard anemias, clotting issues, hyperlipidemia, and irritation and gout
• Endocrine drugs
• Chemotherapeutic and immunologic drugs
• Toxicology
• detailed topics (perinatal, geriatric, and dermatologic pharmacology)
• Botanical and "food supplements," and over the counter medications
• Prescribing

Also during this edition:
• Drug precis Tables finish so much chapters, supplying a concise precis of an important drugs
• normal innovations in relation to newly came upon receptors, receptor mechanisms, and drug transporters
• Descriptions of vital new medicinal drugs, together with monoclonal antibodies

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Extra resources for Basic and Clinical Pharmacology (12th Edition) (LANGE Basic Science)

Sample text

3. Receptors mediate the actions of pharmacologic agonists and antagonists. Some drugs and many natural ligands, such as hormones and neurotransmitters, regulate the function of receptor macromolecules as agonists; this means that they activate the receptor to signal as a direct result of binding to it. Some agonists activate a single kind of receptor to produce all their biologic functions, whereas others selectively promote one receptor function more than another. Other drugs act as pharmacologic antagonists; that is, they bind to receptors but do not activate generation of a signal; consequently, they interfere with the ability of an agonist to activate the receptor.

When this process occurs at a rate faster than de novo synthesis of receptors, the total number of cell-surface receptors is reduced (down-regulated), and the cell’s responsiveness to ligand is correspondingly diminished. A well-understood example is the EGF receptor tyrosine kinase, which undergoes rapid endocytosis followed by proteolysis in lysosomes after EGF binding; genetic mutations that interfere with this process cause excessive growth factor-induced cell proliferation and are associated with an increased susceptibility to certain types of cancer.

For example, several catabolic actions of the glucocorticoid hormones lead to increased blood sugar, an effect that is physiologically opposed by insulin. Although glucocorticoids and insulin act on quite distinct receptor-effector systems, the clinician must sometimes administer insulin to oppose the hyperglycemic effects of a glucocorticoid hormone, whether the latter is elevated by endogenous synthesis (eg, a tumor of the adrenal cortex) or as a result of glucocorticoid therapy. In general, use of a drug as a physiologic antagonist produces effects that are less specific and less easy to control than are the effects of a receptor-specific antagonist.

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