By Junzo Kigawa, Tsunehisa Kaku, Toru Sugiyama, Steven G Silverberg
Clear telephone carcinoma (CCC) of the ovary with its specified medical and organic gains has attracted nice realization, and demands the book of a really expert publication at the topic. this can be the 1st atlas that has narrowed its concentration to CCC. printed listed here are the common and variable histological good points of CCC and similar tumors. 1000s of high quality images aid the reader to acknowledge the pathological positive aspects and scientific manifestations of CCC and to formulate diagnoses optimistically and thoroughly. info are in keeping with the foreign valuable pathological assessment of the JGOG/GCIG3017 scientific trial during which specialists around the globe participated. utilizing a digital slide procedure, attention-grabbing and demanding beneficial properties of CCC have been chanced on within the evaluate of 652 situations. This e-book offers the latest info at the categorization and category of CCC: development styles (papillary, tubocystic, good, and adenofibromatous), cellphone varieties (classical hobnail and transparent mobilephone, eosinophilic, oxyphilic, and oncocytic), stromal alterations (hyalinized, necrotic, hemorrhagic, lymphocytic infiltrative, luteinized, and psammomatous calcification), presence of endometriosis and odd endometriosis, and borderline/atypical proliferative tumors. The Atlas of transparent mobile Carcinoma of the Ovary is a useful diagnostic source for pathologists and gynecologic oncologists.
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Extra info for Atlas of Clear Cell Carcinoma of the Ovary: A Pathological Guide
Am J Surg Pathol 34:984–993 3 Typical Histopathology 4 Histopathologic Variations Oxyphilic differentiation is seen at least focally in at least half of ovarian CCCs, is prominent in 25–30 %, and may be the dominant (or occasionally the only) cell type in 5 % or less. The oxyphil cells, as in other tumors and other organs, are characterized by large quantities of amphophilic cytoplasm, often with enlarged atypical nuclei, and generally with no mitotic activity (Figs. 13). These cells may be oncocytes, but they have never been shown to be packed with mitochondria like true oncocytes.
1). In any event, the important fact to remember is that benign-appearing clear cell tumor foci with or without (Fig. 2) atypia are seen frequently within CCC; it is not known whether in this situation these foci are biologically benign or malignant. On the other hand, when an ovarian tumor consists exclusively of clear cell cystadenoma, adenofibroma, or borderline tumor on initial sections, it is certainly recommended to submit additional sections to rule out CCC manifested by stromal invasion.
31 As in any ovarian carcinoma, focal or extensive necrosis is common, as illustrated in this figure 30 Fig. 32 Another large field of necrotic tumor. More viable tumor is not present, so it might be difficult to make the appropriate diagnosis 4 Histopathologic Variations Fig. 35 Foci of stromal edema are rarely present, probably also indicating nearby necrosis Fig. 33 Cholesterol clefts are occasionally found within CCC Fig. 36 Occasionally, large amounts of stromal mucinous material are present Fig.