Download Advances in Molecular Toxicology. by James C. Fishbein PDF

By James C. Fishbein

Toxicology is the research of toxins, and this sequence information the research of the molecular foundation during which an unlimited array of brokers encountered within the human surroundings and produced via the human physique itself take place themselves as pollution. no longer strictly constrained to documenting those examples, the sequence can also be enthusiastic about the complicated internet of chemical and organic occasions that supply upward thrust to toxin-induced indicators and ailment. the recent applied sciences which are being harnessed to investigate and comprehend those occasions may also be reviewed through best staff within the field.

Volume eight of Advances in Molecular Toxicology maintains within the culture of sampling commonly from all corners of this varied self-discipline.

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1. INTRODUCTION Nutrients and food toxicants are two sides of the same coin. Since we ingest hundreds of kilograms of food and drink yearly, we are potentially exposed to a wide range of toxicants, some of which are inherent to food and some from external sources. Naturally inherent toxins include for instance reaction products of precursors naturally present in the food matrix during the cooking processes [1,2]. Toxins introduced to food and drink intentionally include different agents used to improve the food quality or serve as preservative or reaction products thereof [3,4].

The algal metabolite yessotoxin affects heterogeneous nuclear ribonucleoproteins in HepG2 cells, Proteomics 9 (2009) 2529–2542. [116] M. , Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line, Mol. Med. Rep. 4 (3) (2011) 547–552. [117] M. , Yessotoxin induces apoptosis in HL7702 human liver cells, Mol. Med. Rep. 5 (1) (2012) 211–216. R. , Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins, J. Exp. Biol. 208 (Pt 22) (2005) 4345–4354.

Polyhydroxylated amide analogs of yessotoxin from Protoceratium reticulatum, Toxicon 45 (1) (2005) 61–71. [81] M. , Isolation and structure of Yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning, Tetrahedron Lett. 28 (1987) 5869–5872. [82] M. , Two new analogs of yessotoxin, homoyessotoxin and 45-hydroxyhomoyessotoxin, isolated from mussels of the Adriatic Sea, Nat. Toxins 5 (3) (1997) 107–110. [83] P. , Yessotoxin in mussels of the northern Adriatic Sea, Toxicon 35 (2) (1997) 177–183.

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