Download A Research Annual by Paul M. Wassarman (Eds.) PDF

By Paul M. Wassarman (Eds.)

The inaugural quantity of Advances in Developmental Biology and Biochemistry paints a slightly extensive stroke during the box. development formation and mobile communique in the course of animal improvement, in addition to Y chromosome functionality in the course of mammalian improvement, are significant issues of this quantity. a number of experimental structures, together with mice, flies, and worms are thought of.

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EXPERIMENTAL APPROACHES TOWARD THE ANALYSIS O F VERTEBRATE Wnt GENE FUNCTION The sophisticated genetics of Drosophila has provided a picture of the general scheme of action of wg, at least in its early embryonic phase. Time, and the cloning of other segment polarity genes. will clarify the molecular framework of wg action. In vertebrates. the experimental approaches are. in many respects, more limited. However, they have yielded some fascinating results. The strategies fall into two classes: ( I ) ectopic expression to disrupt the normal localized distribution of Wnr gene product; and (2) the generation of null alleles by homologous recombination to identify the developmental consequence of the absence of Wnr gene expression.

IV. Wnr- I in Vertebrate Development . . . . . . . . . . . . . . . . V. Drosophilu Wnr- I /Wingless: Role and Regulation . . . . . . . . . . VI. Evolutionary Conservation of Wnr- I ActionThe Drosophilu-Vertebrate Connection . . . . . . . . . . . . . . VII. The Wnr Superfamily-Signaling Molecules with Multiple Developmental Roles . . . . . . . . . . . . . . . . . . . . . A. Mouse .................................................. B.

McLaren. , and Page. D. C. (1989) Duplication, deletion, and polymorphism in the sexdetermining region of the mouse Y chromosome. Science 243:78-80. Maxson. S. , Didier-Erickson. A.. and Ogawa. S . (1989) The Y chromosome, social signals, and offense in mice. Neural Biol. 52:251-259. Maxson. S. C.. Ginsberg. B. E.. and Trattner, A. (1979) Interaction of Y-chromosomal and autosomal gene(s) in the development of intermale aggression in mice. Behav. Genet. 9219226. Miklos. G . G . ( 1974) Sex chromosome pairing and male fertility.

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